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@#Alzheimer''s disease (AD) has brought to us huge medical and economic burdens, and so discovery of its therapeutic drugs is of great significance.In this paper, we utilized knowledge graph embedding (KGE) models to explore drug repurposing for AD on the publicly available drug repurposing knowledge graph (DRKG).Specifically, we applied four KGE models, namely TransE, DistMult, ComplEx, and RotatE, to learn the embedding vectors of entities and relations on DRKG.By using three classical knowledge graph evaluation metrics, we then evaluated and compared the performance of these models as well as the quality of the learned embedded vectors.Based on our results, we selected the RotatE model for link prediction and identified 16 drugs that might be repurposed for the treatment of AD.Previous studies have confirmed the potential therapeutic effects of 12 drugs against AD, i.e., glutathione, haloperidol, capsaicin, quercetin, estradiol, glucose, disulfire, adenosine, paroxetine, paclitaxel, glybride and amitriptyline.Our study demonstrates that drug repurposing based on KGE may provide new ideas and methods for AD drug discovery.Moreover, the RotatE model effectively integrates multi-source information of DRKG, enabling promising AD drug repurposing.The source code of this paper is available at https://github.com/LuYF-Lemon-love/AD-KGE.
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BACKGROUND/AIMS: The Crohn's and Colitis Knowledge (CCKNOW) score does not reflect updated knowledge relating to inflammatory bowel disease (IBD). The aim of this study was to develop, validate, and apply a novel tool to measure disease-related knowledge in IBD patients. METHODS: A questionnaire composed of 24 items regarding knowledge of IBD was developed: Inflammatory Bowel Disease Knowledge (IBD-KNOW). Discriminate ability of IBD-KNOW was validated in three occupational groups (14 doctors, 20 nurses, and 19 clerks). The CCKNOW and IBD-KNOW were administered to IBD patients. Factors affecting the level of IBD-related knowledge were analyzed. RESULTS: The median Inflammatory Bowel Disease Knowledge (IBD-KNOW) score was significantly different among the three groups for validation (22 doctors, 20 nurses, and five clerks; p < 0.001). The IBD-KNOW showed excellent internal consistency (Cronbach α = 0.952) and high correlation with CCKNOW (Spearman ρ = 0.827, p = 0.01). A total of 200 IBD patients (120 Crohn's disease, 80 ulcerative colitis) completed questionnaires. Multivariate analysis showed that a higher IBD-KNOW score than the median was associated with hospitalization history (odds ratio [OR], 2.625; p = 0.003), high education level (OR, 2.498; p = 0.012), and information acquired from patient organization (OR, 3.305, p = 0.035). CONCLUSIONS: The IBD-KNOW demonstrated excellent test characteristics. Hospitalization history, education level, and information acquired from patient organization play an important role in correct IBD-related knowledge.
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Humans , Colitis , Crohn Disease , Education , Hospitalization , Inflammatory Bowel Diseases , Multivariate Analysis , Occupational Groups , UlcerABSTRACT
Objective To investigate the effect of self efficacy and coronary heart disease knowledge on health literacy of young and middle-aged patients with coronary heart disease.Methods Investigation was conducted among 500 patients using general questionnaire,chronic health literacy scale,self-efficacy scale and coronary heart disease knowledge questionnaire.Results The score of health literacy for young and middle-aged patients was (97.76± 15.45),and 57％ of the patients had good health literacy.Self-efficacy and coronary heart disease knowledge were positively correlated with health literacy (r=0.301,r=0.309;P＜ 0.05).Multiple regression analysis showed that self-efficacy (β=0.210),coronary heart disease knowledge (β=0.226) were significant factors of health literacy(both P＜0.01).Conclusion The self-efficacy and coronary heart disease knowledge have impact on the health literacy.The more self-efficacy and coronary heart disease knowledge,the higher health literacy.
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El VIH/SIDA en Colombia afecta a la población joven y sexualmente activa. La realización de estudios conductuales permite monitorear indicadores que definen aspectos del comportamiento que son fundamentales en la propagación de la enfermedad. En esta línea, se busca describir los conocimientos, actitudes y prácticas en 212 adolescentes estudiantes de noveno, décimo y undécimo grado, de un colegio público del Distrito de Santa Marta frente a la enfermedad del VIH-Sida. El presente es un estudio descriptivo transversal que obtuvo los siguientes resultados: 91% ha recibido información acerca de VIH/Sida, 68% la recibió en la escuela, 18% no reconoce el VIH-Sida como ETS; el 98% desconoce otras ETS como la candidiasis y tricomoniasis; el 98% no considera el consumo de alcohol y droga como factor de riesgo para contraer ETS, entre otras. Se concluye que la mayoría de los adolescentes no tienen los conocimientos suficientes sobre la enfermedad del VIH/Sida, lo cual constituye un factor de riesgo.
In Colombia, HIV-AIDS affects the population of young and sexually active people. To perform behavioral studies allows the monitoring of indicators that define behavioral aspects that are fundamental in the spread of the disease. In this regard, this descriptive cross-sectional study search to describe the knowledge, attitudes and practices in 212 adolescents students of 9, 10 and 11 grade of a public school in the District of Santa Marta, towards the disease of HIV-AIDS. The results were the following: 91% of the teenagers received information about HIV -AIDS, 68%, received it at school; 18% did not recognize HIV-AIDS as a STD; 98% did not know other STDs such as candidiasis and trichomoniasis; 98% did not consider alcohol and drug use as a risk factor for contracting STDs, among others. It is concluded that the majority of adolescents do not have sufficient knowledge about HIV-AIDS, which is a risk factor.
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Adolescent , HIV , AttitudeABSTRACT
Objective To investigate the knowledge level among patients with ulcerative colitis, and analyze its influencing factors. Methods A total of 147 patients with ulcerative colitis were recruited by using Chinese version of inflammatory bowel disease knowledge questionnaire to assess their knowledge level. The influencing factors were explored by using general information questionnaire and self-efficacy questionnaire of inflammatory bowel disease. Results The total score of disease knowledge among patients with ulcerative colitis was (6.58 ± 1.57) points, Correct rate of disease knowledge was 28.6%; the total score of self-efficacy was (227.45 ± 32.25) points, the score index was 78.28%. The educational level, duration of disease, patients′ age and management of medical and nursing were the influencing factors of disease knowledge, which could explain 44.3% of total variation. Conclusions The knowledge level among patients with ulcerative colitis needs to be improved.Nursing staff should be based on influencing factors, pay attention to improve the knowledge level of patients with nursing intervention or health education,through a variety of ways to meet the patients need of disease knowledge, improve theirquality of life.
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Background: Sickle cell disease is a condition in which an individual has inherited two abnormal hemoglobin genes at least one of which is hemoglobin S (HbS) and the resulting symptomatology or pathology is attributed to the sickling phenomenon. About 5% of the world’s population carries genes responsible for hemoglobinopathies and each year about 300 000 infants are born with major hemoglobin disorders including more than 200 000 cases of sickle-cell anemia in Africa. Sickle cell anemia is a very common disorder in Nigeria with birth rate of about 1 in 50 and about 150,000 children are born annually with sickle cell anemia in Nigeria alone. The study aimed to explore the knowledge and attitude of nursing students about premarital screening for sickle cell disease. Methods: A descriptive, cross-sectional study was conducted using self-administered semi-structured questionnaire among 176 students. Results: Majority of respondents knew sickle cell disease and also knew their genotype 97.6% and 71% respectively, although up to 9.1% selected blood group as their genotype. More than half of respondent (51.7%) said sickle cell disease can be transmitted through blood, 55.1% of respondent said they think government should prohibit marriage between incompatible couples with regard to sickle cell disease, Only about one third (34.1%) of respondent have good knowledge of SCD, and 34.3% of respondent have good knowledge of premarital screening for SCD, More than half (55.4%) of respondent have good attitude regarding premarital screening for SCD. Conclusion: The study shows that the respondent have poor knowledge of sickle cell disease and premarital screening though more than half of the respondent have good attitude towards premarital screening. The results of this study reflect the importance of health education as a keystone in improving knowledge and attitude towards premarital screening for sickle cell disease.
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Objective To study the effect of the health education path on health education in patients with diabetes.Methods According to random number table method,100 type 2 diabetes mellitus(T2DM)patients were divided into control group and health education path group.Health education path group received health education through the health education path and the control group by traditional methods.The rate of diabetes-related knowledge mastery and the control of blood glucose in two groups were compared. Result The rate of diabetes-related knowledge mastery and the control of blood glucose in the health education path group were significantly better than those of the control group(P<0.05,for both).Conclusion Health education according to health education path to the patients with diabetes can increase the degree of knowledge and the control effect of blood sugar.